商品信息產品英文名稱HumanTransferrinprotein產品中文名稱重組人轉鐵蛋白（TF）別名PRO2086Protein

商品信息

產品英文名稱	Human Transferrin protein
產品中文名稱	重組人轉鐵蛋白（TF）
別名	PRO2086 Protein; TFQTL1 Protein; HEL-S-71p Protein, Human; PRO1557 Protein; Transferrin Protein,Siderophilin, partially saturated

商品屬性

標簽	無標簽
種屬	人
序列	Amino acid sequence derived from Human Transferrin protein isoform (P02787, Met 1-Pro 698) with a polyhistidine tag at the C-terminus was expressed.
活性	檢測進行中
蛋白長度	重組人轉鐵蛋白由690個氨基酸組成，預測分子量為76.6 kDa。 在還原條件下，SDS-PAGE中人轉鐵蛋白的表觀分子量約為70-100 kDa。
純度	≥ 95 % ，使用SDS-PAGE檢測
特點&優勢	采用 LAL 法檢測，每 1 μg 蛋白質中的 EU 含量小于 1.0。
產品形式	凍干粉，凍干緩沖液為無菌的 PBS，pH 7.4。
基因ID	7018
蛋白序列鏈接	/uniprot/P02787
使用中注意事項	開蓋使用前，請先離心。本產品為凍干粉，推薦用該產品配套的Reconstitution Buffer進行復溶，且濃度不低于100 µg/mL。客戶可根據后續的實驗需求，進行進一步的稀釋。
保存建議	本產品為凍干粉形式，建議：將凍干粉的重組人轉鐵蛋白（TF）產品保存于-20℃以下的干燥環境中。本產品溶解之后，可在4℃保存2-7天，長期使用請置于-20℃以下。為長期保存，推薦添加載體蛋白（0.1% HSA或者BSA），并酌情分裝保存，避免反復凍融。
運輸條件	常溫運輸
警告	本文列出的產品僅供研究使用，不適用于人類或臨床診斷。我們產品所推薦應用，不是建議使用我們的產品去違反任何或許可證。對于使用本產品可能發生的侵權或其他違規行為，我們不承擔任何責任。

附加信息

背景

Transferrin (Tf),is an iron transporter, which is mainly biosynthesized in the liver, and it can also be biosynthesized in the brain; i.e., by oligodendrocytes and the choroid plexus, cerebrospinal fluid (CSF) producing tissue. The CSF contains two Tf isoforms, brain-type Tf and serum-type Tf, which differ in their glycan structures. Brain-type Tf is uniquely glycolsylated with biantennary asialo- and agalacto-complex type N-glycans that carry bisecting β1,4-GlcNAc and core α1,6-Fuc.The glycans of serum-type Tf in the CSF are similar to those of Tf in serum. Biochemical analyses reveal that the apparent molecular size of brain-type Tf is smaller than that of serum-type Tf, and that hydrophobic patches are exposed on brain-type Tf as demonstrated by hydrophobic probe binding studies. Research indicates that brain-type Tf levels is decreased in idiopathic normal pressure hydrocephalus, in which CSF production is suspected to decrease, while brain-type Tf increased in spontaneous intracranial hypotension, in which CSF production is suspected to increase. These results suggest that brain-type Tf could be a biomarker of altered CSF production.

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